The church was built to shelter the historic Vladimir icon of the Mother of God. The icon traveled to Jerusalem, Constantinople and then Kiev, where Prince Andrey Bogolyubskiy bought it and brought it to the ancient Russian city of Vladimir after which it is named. Subsequently the icon was credited by the Orthodox Church with freeing Moscow from the control of the Mongols.

The founding of the cathedral dates to 1746 in the house of a certain Yakimov where the first iconostasis was assembled. On August 25, 1748 a new wooden church was dedicated in the name of the Vladimir Icon of the Mother of God. On the following day Empress Elizabeth attended a special church service in honor of the new church's opening.

Because the construction of the current stone church dragged on for more than 20 years and several different architects were involved in its design and construction, the cathedral is not credited to any one architect.

With its unique combination of baroque and classical features, the church is an important addition to St. Petersburg's architectural history. No other church in the city can claim a design quite like the Vladimir Icon of the Mother of God Church, with its five different-sized onion-shaped cupolas rising into the sky and topped off with glistening Orthodox crosses, and including five sections, two stories and three porticos.

In 1831, a stone portico was added to the main building with two stairways leading to the second floor, designed by A. Melnikov. In 1833, another two-story portico was built on the northern and southern facades of the church including a two-story room for a staircase, designed by A. Golm. In 1848-1849 a fourth tier was added to the bell tower to a plan by architect F. Rusk. In 1850-1851 a fence was installed around the church, and two stone chapels were also added. The Vladimir Icon of the Mother of God Church, bell tower and chapels were also gilded at this time.

Although most of the church's treasures were looted during the Revolution, the incredible iconostasis on the church's upper level survived. It is one of only a very few of its kind in Russia is now an architectural monument and well worth seeing, and was created in the middle of the 18th century by Italian sculptor Bartolomeo Rastrelli.

The Vladimir Icon of the Mother of God Church is located in one of the favorite areas of the city's intelligentsia, and has had many notable parishioners, including Fyodor Dostoyevsky.

A vigorous restoration of the church began in the 1970s, including restoration of the facade and icons. Nevertheless, the effects of years of neglect have been difficult and slow to correct. In 1990, after the church had been returned to the Russian Orthodox Church, the first services where conducted in what observers described then as a gloomy and cold environment where there were only two icons donated by church parishioners. Moreover, the church did not have a cross for more than a year after it reopened.

 Адрес: Vladimirskiy Ave., 20, St. Petersburg 191025, Russia
 Телефон(ы): 8 (812) 312-19-38